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What Is Ozone Therapy For Knee Pain

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How Practitioners do Ozone Joint injections into knee | Alternative Prolo therapy BACK

Oxygen is vital for effective healing, recovery from disease, and a robust immune system. You can now receive oxygen in the form of ozone therapy at Meeting Point in Philadelphia, Pennsylvania, under the expert supervision of integrative, regenerative, and Functional Medicine experts Dr. Steve Matta, DO, MBA, CAQSM, and Mary Anne Matta, MS, MA, LAC. We use ozone therapy and Prolozone to treat a range of disorders and promote the growth of healthy new tissues. Call the Meeting Point office for more information, or schedule a consultation by requesting an appointment online today.

Ozone Gas In Musculoskeletal Disorders

A detailed and precise analysis of ozone gas and musculoskeletal disorders is presented in the journal Medical Gas Research, September 2018.

Here researchers examined the role of ozone over a myriad of disorders including lumbar facet joint syndrome, subacromial bursitis, carpal tunnel syndrome, hip bursitis, shoulder adhesive capsulitis, herniated disc, and temporomandibular joint disorder. Here are some learning points from that research:

Effectiveness in temporomandibular joint disorder

The researchers found that the use of ozone therapy has been much more effective than medication therapy in patients with temporomandibular joint disorder and high pain scores. Ozone can relieve pain and increases the maximum voluntary interincisal mouth opening values. The researchers speculated that ozone gas promotes new cartilage growth as well as reduce inflammation.

Effectiveness for herniated disc

Effectiveness for shoulder pain

Here the researchers reported on a single case history of a 57-year-old woman who had shoulder pain reduction and increased range of motion. Next, they reported on suggested anti-inflammatory benefits in patients with shoulder adhesive capsulitis.

Effectiveness for hip bursitis

Prolozone Is A Homeopathic/oxygen

ProlozoneĀ® treatments do not contain any drugs, steroids, narcotics or NSAIDs, are performed in the office and do not require surgery. Dr. Krasnick performs injections under ultrasound guidance, so he is highly accurate in injecting the treatment to the exact location needed. These treatments allow the bodys own natural healing powers to recover and restore to health.

If you are looking for a non-surgical, drug-free, natural, alternative pain treatment, then contact us at to schedule a consultation with Dr. Krasnick.

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Ozone Therapy For Joint Pain

Ozone has been studied in the treatment of a variety of diseases and health conditions. The results of these studies show that the potential of this molecule to create a drastic impact on your health is very high. But what exactly is ozone and for what conditions can it be used? One condition this therapy has shown to be effective in treating is joint pain, so lets take a closer look at just how this is possible.

What are Common Causes of Joint Pain?

Osteoarthritis is a very common inflammatory disorder of the joints characterized by pain, stiffness, sensation of grinding, loss of cartilage, and formation of bone spurs in the affected area. OA is a progressive disease and affects the knee joint most commonly. It occurs more frequently in joints that have been overused, AKA in highly active people. Current medical treatment of this disease revolves around controlling pain and inflammation with medications such as Ibuprofen, which do nothing to actually slow the progression of the disorder. But fear not, there is a therapy that is showing to be highly effective in regenerating joint integrity and controlling guessed it, ozone!

How Ozone Works

Other Uses of Ozone


Bocci V, Borrelli E, Zanardi I, Travagli V. The usefulness of ozone treatment in spinal pain. Drug Design, Development and Therapy. 2015 9:2677-2685. doi:10.2147/DDDT.S74518.

Comparison Of Ozone Therapy And Cortiscosteroid Injections

Ozone treatment or Lower back pain treatment ...

A randomized control trial published in the journal Clinical rheumatology compared the the effects of ultrasound-guided corticosteroid injection with oxygen-ozone injection in patients with knee osteoarthritis. Here are the learning points:

  • This double-blind randomized clinical trial was performed on 62 patients with knee osteoarthritis.
  • The patients were randomly divided into two groups. In the first group 40 mg triamcinolone and in the second group 10 cc oxygen-ozone were injected into the knee joint under ultrasound guidance.
  • Results:
  • Pain, function and range of motion scores were analyzed among the two groups before injection, and one week, one month, and three months after the treatment.
  • Visual Analog Scale improved in both groups.
  • The improvements seen in Visual Analog Scale and Western Ontario McMaster University Osteoarthritis Index scores three months after treatment were in favor of the oxygen-ozone group when compared to the steroid group.
  • There was no significant difference between the two groups in range of motion and joint effusion seen under ultrasound. However, in the oxygen-ozone-receiving group, joint effusion was decreased significantly.
  • The researchers conclusion: Both steroid and oxygen-ozone injections are effective in patients with knee osteoarthritis. Our study showed that the effects of oxygen-ozone injection last longer than those of steroid injection to the knee joint.
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    Knee Pain Ghutno Ke Dard Ka Ilaj

    Ozone is a highly soluble gas with great oxidizing activity. In contact with biological fluids ozone forms lipid oxidation products and reactive oxygen species. These substances react with white blood cells triggering the production of cytokines, proteins strongly conditioning inflammatory reactions, and red blood cells enhancing the oxygen supply to tissues

    Ozone is used to treat many painful syndromes affecting the joints, muscles and tendons even when peripheral neurological impairment is present . Its painkilling mechanism is thought to be based on stimulation of the anti-nociceptive apparatus mediated by endogenous opioids and serotonin thereby raising the pain threshold. In addition, the marked anti-inflammatory properties of ozone reduce edema, joint swelling and compression on nerve root structures. Ozone favors tissue hyper oxygenation following increased vascularization due to neoangiogenesis improving local tissue trophism and the inhibitory capacity of inflammatory metabolites


    Indications for Ozone Therapy

    Pain may be invalidating and progressive,

    Exacerbated by movement .

    Swollen knee reflects the synovial membrane reacting to joint inflammation

    Inflammatory disease due to overloading,

    Patellar tendinitis,

    Synovitis during inflammatory arthritis, bursitis, knee pain caused by joint cartilage degeneration due to femoral-rotularchondropathy, knee pain following surgery.

    What Is Prolotherapy And How Does It Work

    Prolotherapy is used to treat the tendons and ligaments that are often compromised due to ongoing sport injuries, aging or everyday irritation. Prolotherapy involves injecting a solution, Dextrose, into the tendons and ligaments that support the painful joint. The injection causes inflammation in the joint which triggers an increase in blood flow and nutrients to the area. With this surge of blood flow and nutrients, the body has what it needs to begin to repair itself.

    Prolotherapy treatments lead to improved joint function and significantly reduce pain. This treatment plan is an affective natural drug free solution to joint pain. To learn more about Prolotherapy .

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    What Is Daradia: The Pain Clinic

    Daradia feels your pain and sufferings. Daradia: The pain clinic is a unique pain clinic or pain management center, conveniently located at KOLKATA. It is the first multidisciplinary Pain Clinic at Kolkata with the facilities of diagnosis, treatment, research and training. This pain clinic provides extensive diagnostic and therapeutic services for management of most kinds of pain. This clinic has a multi-disciplined team dedicated to the management of pain based on comprehensive approach to each patient as individual needs. The patients may suffer from different kinds of acute or chronic pain conditions like HEADACHE, FACIAL PAIN, NECK PAIN, SHOULDER PAIN, LOW BACK PAIN, KNEE PAIN, JOINT PAIN etc. due to variety of diseases like migraine, trigeminal neuralgia, arthritis, slipped disc, spondylosis, cancer etc. In this pain clinic we use a blend of different pain management modalities starting from yoga, meditation, pranayam to radio-frequency ablation, spinal cord stimulator, Percutaneous Discectomy, vertebroplasty & Ozone Nucleolysis.

    Cryoneurolysis, a type of Cryoablation done to relieve intractable pain is a new addition in interventional pain management after advent…

    Ozone Prolotherapy Patient Spotlights

    Long term knee improvement with single prolozone treatment

    I was involved in an accident nearly 50 years ago that damaged my lower back and neck and created chronic pain. I consulted a highly regarded neuro surgeon and he said the damage was too extensive for traditional surgery to be effective. He recommended that I use whatever means were available to help relieve the pain such as massage, chiropractic and acupuncture therapies. I also had laser disc surgery in both my low back and neck that trimmed bulging and torn discs. All of the procedures and therapies helped but there was still some pain that would not go away due to tendon and ligament damage. Within a few hours of having my first prolozone injections that pain was gone. I had first injections 3 months ago and I am still pain free.

    Dan Gimore-Prolozone May 31, 2016

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    Join The American Academy Of Ozonotherapy

    I have been training doctors in the Prolozone technique for over fifteen years. Of course the ones who learn the fastest are the ones who are already versed in classical Prolotherapy, and/or are used to injecting tissue. Because of their understanding of anatomy, orthopedists, osteopaths, and chiropractors are particularly quick learners. But anyone can do this therapy. It is a very forgiving modality. Remember, its like target practice with a shotgun. Its hard to miss the bulls eye.

    This January, 2011, The American Academy of Ozonotherapy was formed. The AAO is an academy of health professionals dedicated to establishing standards for the art and science of Ozonotherapy, educating the public and other health professionals about the many uses of Ozonotherapy in medicine, and promoting research in Ozonotherapy. Our goal is to enhance the health and well being of people through this safe, inexpensive, and effective therapy. You can learn more about the AAO at

    Clinical Applications From The Literature

    Ozone therapy has excellent versatility in treating musculoskeletal sources of acute and chronic pain . Many studies have been conducted on the use of ozone injections for back pain, especially that related to herniated discs.20-24 These studies have shown positive clinical outcomes with intra-discal or paravertebral ozone injections, with one trial demonstrating better efficacy than steroid infiltration.25 Analgesic effects of ozone have also been demonstrated in the treatment of sciatica,25 headache,26 temporomandibular joint disorder,27 sensitive-tooth pain,28 and radiotherapy-induced proctitis.29

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    Ozone Injections In Combination With Dextrose Prolotherapy Injections

    An August 2021 study in the journal Evidence-based complementary and alternative medicine examined whether ozone injections in combination with dextrose Prolotherapy injections significantly improved knee problems in patients with osteoarthritis. To do this the researchers aimed to compare the effect of hypertonic saline with ozone and hypertonic saline in improving the symptoms of osteoarthritis in the patients.

    • thirty-four adults with painful primary knee osteoarthritis for at least three months were randomized to two groups: ozone plus hypertonic saline 5% and hypertonic saline 5% alone.
    • Prolotherapy was given three times at baseline and then twice at two week intervals.

    The researchers found that in the saline injections with ozone and the saline injections without ozone groups, the results were about the same. Both groups did report improvements in pain, stiffness and function. The researchers concluded: The results showed that intra-articular prolozone therapy and hypertonic saline injection can lead to improvement of pain and function in patients with knee osteoarthritis at the same status without any significant difference.

    The Best Ozone Generator For Ozone Therapy At Home

    Knee Pain Treatment: Non

    16. Turn the lever on the syringe filling station to open the syringe port.

    17. Fill the syringe with around 20 cc of ozone/oxygen mix if you will inject one knee.

    18. Close the lever on the syringe filling station when the syringe is 20 cc full.

    19. Turn the ozone generator off.

    20. Close the regulator by setting it to zero.

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    Comparison Of Ozone Therapy And Hyaluronic Acid Injections And Dextrose Prolotherapy Injections

    An October 2018 study in the Journal of Pain Research compared ozone treatments with Hyaluronic Acid Injections or dextrose Prolotherapy injection as the control group.

    Please note that this is not a comparison of Prolozone to the other treatments, this is a comparison of ozone alone.

    The researchers wrote that the existing body of evidence had well demonstrated that ozone injection was evidently effective for short-term management of mild-to-moderate knee osteoarthritis patients . But the main challenge was on longer periods of time in which different studies had declared heterogeneous results.

    The researchers gathered dated from a serious of randomized control trials and made these observations:

    • Short-term effectiveness of intra-articular ozone is better than placebo and corticosteroids
    • Short-term effectiveness of intra-articular ozone is equal to that of dextrose prolotherapy or hyaluronic acid injections.
    • However, at 36 months after injections, the therapeutic efficacy of ozone decreased to a level, slightly lower than that of dextrose prolotherapy or hyaluronic acid injections.
    • After 6 months, ozone therapy was not associated with significant improvement of Range of Motion and functionality

    A 2015 study in the journal Anesthesiology and Pain Medicine showed that:

    What Are The Benefits Of High Doze Ozone Therapy For Joint Pain

    High Doze Ozone Therapy is an exciting new addition to American Regenerative Clinic. The therapy is an advanced technique that is very popular in Europe, particularly Germany. The procedure involves removing blood from the patient, mixing the blood with ozone, and putting the blood back into the same vein. This advanced procedure is able to increase the volume of blood from the traditional 60 ml to 2 litres. At this volume, the treatment not only boosts immune function, it stimulates new cell growth and kills bacteria. To read more about the benefits of this therapy .

    Contact us today to discuss how Prolotherapy and High Dose Ozone Therapy can work for you. You can find an American Regenerative Clinic in Bloomfield Hills Michigan and the surrounding areas including Troy, Rochester, Rochester Hills, Bloomfield Twp and Farmington Hills. Your health and your pain management are our priority. We look forward to seeing you soon.

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    Other Localized Effects Of Ozone

    As a powerful oxidizing agent, ozone also has several other effects that are important for tissue repair and regeneration. One is by stimulating growth factor production and release. One paper published in 1996 examined the critical role that protein tyrosine phosphorylation events play in proliferation and differentiation. The authors determined that oxidizing agents stimulate growth response events in vascular smooth muscle cells, and also stimulate tyrosine phosphorylation of several proteins including epidermal growth factor receptor. The stimulation of growth factors, especially endothelial factors are important for tissue regeneration to occur.

    But ozone therapy can do more than just stimulate growth factor production and release. It also activates the membrane receptors through which growth factors exert their effects. For example, a paper published in the Journal of Biological Chemistry established a novel role for the mitochondrion as a proximal target specific to oxidant induced signaling and growth factor transactivation.

    The Power Of Ozone Shop

    Prolozone Injection for Knee Pain: Is It Worth It?!

    6. Plug the ozone generator into the power supply.

    7. Open the valve of the oxygen tank, just half a turn. Watch the regulator and see how the gauge jumps up. It shows you how much oxygen is left in the tank.

    8. Open the regulator to 1/2 LPM.

    9. Flush the lines: Count to 15 to let pure oxygen flow through the lines, the syringe filling station, and the filter.

    10. Flush the syringe: screw it onto the syringe port of the syringe filling station and fill with pure oxygen.

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    Regenerative Medicine Therapy In Mankato Mn And Clinton Sc

    Following prolozone therapy, you can expect your joint pain to gradually decrease and to hopefully go away completely. Many patients have reported experiencing a 50-80% decrease in their joint pain. Pre- and post-treatment X-rays have shown that knee joints developed an increase in the thickness of collagen following the prolozone treatment.

    Prolozone therapy is nearly risk-free. A very small number of patients who have been treated with prolozone therapy have experienced an allergic reaction or pain at the injection site, but otherwise, patients report no ill side effects.

    If you suffer from chronic pain or lack of mobility in one or more joints, prolozone therapy may be the right choice to address your joint pain. To schedule a consultation, contact our caring staff today by calling 388-7488 or fill out our online appointment request form now. We look forward to helping you enjoy less pain and more living.

    Ozone Therapy For Knee Osteoarthritis: History And Mechanisms Of Action

    Injections are gaining popularity in healthcare, and you can find a practitioner in just about every city who is willing to perform any number of different types cortisone, PRP, ozone, stem cell the list keeps growing each year. This post, as well as the next few, will focus on what exactly these different injections are, how they work, and what the current research shows their efficacy to be. Today we will look at a brief history of ozone therapy and its mechanisms of action in relation to treating knee osteoarthritis, where the majority of the musculoskeletal research has focused to date.

    Ozone Therapy History

    Ozone, or O3, is an atmospheric gas that rapidly decomposes to oxygen. It is an excellent example of a compound with hormetic properties, meaning that it has beneficial effects in low doses and detrimental effects in large doses .1 Ozone therapy first appeared in the 1800s, with the first medical ozone generator patent going to the one and only, Nikola Tesla .2 It gained traction during WWI, when it was used as a topical disinfectant for soldiers wounds, but it fell out of favor after the war until the 1980s and 90s when it began to gain steam again as a treatment for HIV . Ozone therapy has remained a relatively well-known treatment since then, with the first large-scale look at intra-articular injections beginning in the 2010s.

    Ozone Therapy Mechanisms of Action

    Increased Antioxidant Capacity



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