Gabapentin May Cause Side Effects Tell Your Doctor If Any Of These Symptoms Are Severe Or Do Not Go Away:
- uncontrollable shaking of a part of your body
- double or blurred vision
- swelling of the hands, feet, ankles, or lower legs
- back or joint pain
- difficulty breathing bluish-tinged skin, lips, or fingernails confusion or extreme sleepiness
Gabapentin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s MedWatch Adverse Event Reporting program online or by phone .
Is It Right For You
If you are battling with constant nerve pain and you think you need to take gabapentin to alleviate it, you need to visit your medical practitioner. When you do, tell your medical practitioner the following things:
- If you are allergic to any ingredient or medicine
- If you are currently on any medication or herbal medicine
- If you are pregnant or breastfeeding or if you plan to conceive in the future
- If you have a kidney issue
- If you have or have had a history of alcohol, recreational drug, or over the counter medication abuse
Anyone diagnosed with nerve pain should consult with their medical practitioner on whether they should take gabapentin to treat it.
Risks During Pregnancy And When Breastfeeding
People who are pregnant and those who intend to become pregnant should tell a doctor before taking gabapentin.
Research from 2020 suggests that taking this drug during pregnancy may be associated with a higher risk of cardiac malformations in the fetus, a condition called small for gestational age, and preterm birth.
However, it is also essential to control seizures during pregnancy, so pregnant people should only take the drug if it is absolutely necessary.
People should never start or stop taking gabapentin for seizure control before talking with a doctor. They will assess the potential risks and benefits.
After childbirth, gabapentin passes into breast milk. At low levels, it may not affect the infant. However, it is best to discuss this issue with a doctor before breastfeeding.
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What Do People Use Gabapentin For
Gabapentins primary use is to prevent or control seizures. It works by calming nerve activity to reduce seizure intensity or occurrence.
Children and adults can take this drug. The brand-name drug Neurontin can treat one form of epilepsy in children as young as 3 years old. Some people take other medications with gabapentin to control epilepsy symptoms.
Gabapentin can also help reduce post-herpetic neuralgia, which refers to a burning or stabbing nerve pain that is a common complication of shingles.
Extended-release gabapentin tablets can treat RLS, which is a condition characterized by uncomfortable sensations in the legs and a strong or irresistible urge to move the lower limbs.
Individuals taking gabapentin should talk with a doctor about any problems they experience while doing so, especially if they are severe, ongoing, or getting worse.
People taking gabapentin should be aware of the following serious safety concerns.
Gabapentin For Chronic Neuropathic Pain In Adults
There is moderate-quality evidence that oral gabapentin at doses of 1200 mg daily or more has an important effect on pain in some people with moderate or severe neuropathic pain after shingles or due to diabetes.
Neuropathic pain comes from damaged nerves. It is different from pain messages that are carried along healthy nerves from damaged tissue . Neuropathic pain is often treated by different medicines to those used for pain from damaged tissue, which we often think of as painkillers. Medicines that are sometimes used to treat depression or epilepsy can be effective in some people with neuropathic pain. One of these is gabapentin. Our definition of a good result was someone with a high level of pain relief and able to keep taking the medicine without side effects making them stop.
In January 2017 we searched for clinical trials in which gabapentin was used to treat neuropathic pain in adults. We found 37 studies that satisfied the inclusion criteria, randomising 5914 participants to treatment with gabapentin, placebo, or other drugs. Studies lasted 4 to 12 weeks. Most studies reported beneficial outcomes that people with neuropathic pain think are important. Results were mainly in pain after shingles and pain resulting from nerve damage in diabetes.
Quality of the evidence
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What Safety Concern Is Fda Announcing
The U.S. Food and Drug Administration is warning that serious breathing difficulties may occur in patients using gabapentin or pregabalin who have respiratory risk factors. These include the use of opioid pain medicines and other drugs that depress the central nervous system, and conditions such as chronic obstructive pulmonary disease that reduce lung function. The elderly are also at higher risk.
Gabapentin and pregabalin are FDA-approved for a variety of conditions, including seizures, nerve pain, and restless legs syndrome.
Our evaluation shows that the use of these medicines, often referred to as gabapentinoids, has been growing for prescribed medical use, as well as misuse and abuse. Gabapentinoids are often being combined with CNS depressants, which increases the risk of respiratory depression. CNS depressants include opioids, anti-anxiety medicines, antidepressants, and antihistamines. There is less evidence supporting the risk of serious breathing difficulties in healthy individuals taking gabapentinoids alone. We will continue to monitor these medicines as part of our routine monitoring of all FDA-approved drugs.
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What Are The Serious Side Effects Of Gabapentin
If you have any of these symptoms, call your healthcare provider right away:
- Signs of an allergic reaction: If you have a skin rash, hives, itching or swollen, blistered or peeling skin with or without fever contact your healthcare provider. You should also contact your provider if you have trouble breathing or swallowing, wheezing or swelling of your face, lips, throat, eyes, mouth or tongue
- Changes in mood or behavior: Call your provider for any suicidal thoughts or thoughts about dying, suicide attempts, new or worsening depression, anxiety, irritability or feelings of agitation or restlessness. You should also call your provider for trouble sleeping, panic attacks, feelings of aggression or anger, impulsive behavior, extreme increase in activity or talking and other changes in mood or behavior, confusion, inability to focus or memory problems as these can be side effects of your medication.
- Signs of liver abnormalities: Yellowing of your skin or whites of your eyes, dark urine, light-colored stools, vomiting, unusual bleeding or bruising.
- Signs of kidney abnormalities: Trouble urinating, a change in how much urine is passed, blood in your urine, or weight gain and swelling of legs and feet from retaining fluid.
- Other concerning abnormalities: Change in color of your skin to a bluish color on your lips, nail beds, fingers, or toes along with severe fatigue or weakness and unexpected muscle pain.
Data Collection And Analysis
Two review authors independently extracted data and assessed trial quality and potential bias. Primary outcomes were participants with substantial pain relief ), or moderate pain relief . We performed a pooled analysis for any substantial or moderate benefit. Where pooled analysis was possible, we used dichotomous data to calculate risk ratio and number needed to treat for an additional beneficial outcome or harmful outcome . We assessed the quality of the evidence using GRADE and created ‘Summary of findings’ tables.
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What Other Information Should I Know
Keep all appointments with your doctor.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking gabapentin.
If you use a dipstick to test your urine for protein, ask your doctor which product you should use while taking this medication.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
What Should I Know About Storage And Disposal Of This Medication
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the tablets, extended-release tablets, and capsules at room temperature, away from excess heat and moisture . Store the oral solution in the refrigerator.
It is important to keep all medication out of sight and reach of children as many containers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website for more information if you do not have access to a take-back program.
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How Long Does It Take To Work
After you start to take it for nerve pain, you should see an improvement in the intensity of the pain over one to two weeks. However, for some people, it may take longer for gabapentin to work to reduce nerve pain whereas there are others who may feel a difference right away.
You will need to visit your medical practitioner on a scheduled to date so he/she can conclude if the nerve pain medication is working to relieve your pain or not. In the event it is not, they may either increase the dosage or switch your medication for another one.
If you do notice a difference in the level of pain you experience on gabapentin, your medical practitioner will advise you to continue taking it. You cannot become addicted to gabapentin, hence making it safe to take for continuous use.
Even though the chances of becoming addicted are low because its addictive potential is low, you may experience withdrawal symptoms, which is an essential part of physical addiction.
Even though the occurrence of someone becoming addicted is less, if they do become addicted to it, the treatment to stop being dependent on the medication is quite complex, but doable.
Here are common signs of a person who has developed a dependency on gabapentin:
Description Of The Intervention
Gabapentin is licensed for the treatment of peripheral and central neuropathic pain in adults in the UK at doses up to 3.6 grams daily. It is given orally, usually as tablets or capsules, but sometimes as an oral solution . Guidance suggests that gabapentin treatment can be started at a dose of 300 mg per day for treating neuropathic pain. Based on individual patient response and tolerability, the dosage may be increased by 300 mg per day until pain relief is experienced or adverse effects make taking the drug intolerable . US marketing approval for gabapentin was granted in 2002 for postherpetic neuralgia in Europe, the label was changed to include peripheral neuropathic pain in 2006. Gabapentin has the trade name NeurontinTM, and is also available as generic products in some parts of the world.
Gabapentin can also be formulated as an aqueous solution for injection. This formulation is not available commercially or licensed for treatment of any type of neuropathic pain or fibromyalgia.
Gabapentin misuse has been reported, and the consequences documented and systematically reviewed .
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Stat Forecast: Opioids Could Kill Nearly 500000 Americans In The Next Decade
Athens, home to Ohio University, lies in the southeastern corner of the state, which has been ravaged by the opioid epidemic. Despite experience in combating illicit drug use, law enforcement officials and drug counselors say the addition of gabapentin adds a new obstacle. As providers dole out the drug in mass quantities for conditions such as restless legs syndrome and alcoholism, it is being subverted to a drug of abuse. Gabapentin can enhance the euphoria caused by an opioid and stave off drug withdrawals. In addition, it can bypass the blocking effects of medications used for addiction treatment, enabling patients to get high while in recovery.
I dont know if we have a clear picture of the risk, said Joe Gay, executive director of Health Recovery Services, a network of substance abuse recovery centers headquartered in Athens.
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What Dosage Strengths And Forms Does Gabapentin Come In
Gabapentin is available as:
- Gabapentin tablets. Its available as 300- and 600-milligram tablets and 600- and 800-milligram tablets .
- Gabapentin oral solution. The oral solution contains 250 millgrams of gabapentin per 5 milliliter Neurontin or generic gabapentin.
- Gabapentin capsules. Its available as 100-, 300- or 400-milligram gelatin capsules .
- Gabapentin enacarbil, 300- and 600-milligram extended-release tablets .
What Is Gabapentin Approved For
Gabapentin is used to:
- Prevent and control partial seizures. Gabapentin can be used in adults and children age 3 and older who have partial seizures.
- Relieve nerve pain following shingles in adults.Shingles is a painful rash that develops many years after you’ve had chickenpox. The virus that causes chickenpox stays dormant in a portion of your spinal nerve root called the dorsal root ganglion. For whatever reason, this otherwise dormant virus gets reactivated usually by stress causing a shingles rash. Nerve pain following a case of shingles is called postherpetic neuralgia .
- Treat moderate-too-severe primary restless legs syndrome.
The branded gabapentin products Neurontin and Gralise are approved for partial seizures and PHN. The branded gabapentin enacarbil product Horizant is approved for restless legs syndrome and PHN.
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How To Take It
You should take it with a tall glass of water, with or without food. You should never increase your intake of gabapentin without your medical practitioners knowledge and approval. You may notice the benefits of taking gabapentin after a few days or two months, as it differs from person to person.
Others may need to increase the dosage of gabapentin, if required, for it to be effective. In the event you forget or miss your daily dose, you need to take it as soon as you remember. The only time that you should not take it immediately is if it is time for you to take your next dose. If that is the case, you need to skip the missed dose and take the next dose as you would normally do. You should never take two capsules at the same time.
However, gabapentin does not work for everyone. If you do not notice a difference in the severity of your pain after 6 to 8 weeks, you need to stop talk to your medical practitioner before you stop taking gabapentin.
You should never stop taking gabapentin or any other medication for that matter abruptly. If you suddenly stop taking it, you will experience withdrawal symptoms. Your medical practitioner will gradually wean you off them.
Research On The Benefits
Cochrane performs and presents high quality and relevant research on various medications and treatments to increase peoples knowledge about healthcare and help them decide. The website on gabapentin on June 9, 2017.
The authors of the research found clinical trials in which researchers gave gabapentin to adults to treat nerve pain in January 2017. The authors discovered 37 studies that complied with their requirements and performed randomized testing on 5,914 people by treating their nerve pain with gabapentin, placebo, or another form of medication.
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Allegra Comas Acsw Ma
Allegra is an Associate Clinical Social Worker. She earned her masters in social work at Smith College in 2019, and her first masters degree in women and gender studies from San Francisco State University in 2008. Allegra worked as a high school literacy specialist in the Bay Area for six years prior to becoming a clinical social worker/psychotherapist. She is a Los Angeles native, and has dedicated her professional life to community and family services. She is psychodynamically trained, trauma informed and emphasizes the intersection of culture, gender, and sexuality in her clinical practice.