Wednesday, June 15, 2022

Can Marijuana Help With Nerve Pain

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Wilsey Et Al 200: Neuropathic Pain Reduced

THC in Chronic Abdominal Pain

Wilsey et al conducted a double-blind, placebo-controlled crossover study that assessed the effects of smoking cannabis in 38 patients with central or peripheral neuropathic pain. Participants were assigned to smoke either high- or low-dose cannabis or placebo cigarettes. Cigarettes were smoked during treatment sessions using the following regimen: 2 puffs at 60 minutes from baseline, 3 puffs at 120 minutes, and 4 puffs at 180 minutes. Patients were assessed after each set of puffs and for 2 hours afterwards. The primary outcome was spontaneous relief of pain as measured by a visual analog scale.

Pain intensity was comparable and significantly reduced in both treatment groups compared with placebo. At the high dose, some participants experienced neurocognitive impairment in attention, learning, memory, and psychomotor speed only learning and memory declined at the low dose.

How Does Cbd Oil Help With Pain Relief

Cannabidiol, CBD, is known to have an analgesic or pain relieving effect.

CBD doesnt work directly on the CB1 & CB2 cannabinoid receptors in the body its more of a regulator.

While we dont know exactly how CBD works, we believe that it interacts on cannabinoid receptors indirectly and influences other receptors and messaging in the brain. Somehow CBD appears to be doing something to the pain signals sent and received by our bodies which can, in some people, reduce the feeling of pain.

CBD is usually the starting point for pain relief.

Functional Imaging Suggests Thc Disrupts Pain

In a small randomized, double-blind, placebo-controlled trial, THC-induced analgesia correlated with a reduction in functional connectivity between the anterior cingulate cortex and the sensorimotor cortex in patients with chronic radicular nerve pain, reported Haggai Sharon, MD, of the Tel Aviv Medical Center in Israel, and colleagues in Neurology.

Graph theory analyses also showed reduced network connectivity in areas involved in pain processing — specifically in the dorsolateral prefrontal cortex. The connectivity changes correlated with less pain.

“We found a reduction in the functional connectivity, a major measure of brain networking, between brain areas that process aspects of sensation to those that process aspects of emotion and cognition in pain,” Sharon told MedPage Today. “This may mean that the pain-relieving effects of cannabis are mediated by a breakdown of the pain experience, rather than just influencing pain sensation.”

Previous research indicated that THC reduced experimentally induced pain in healthy participants and that this analgesic effect correlated with reduced activity of the anterior cingulate cortex. The anterior cingulate cortex has been shown to be densely populated with cannabinoid-1 receptors which THC activates, Sharon and co-authors noted.

Disclosures

This project was supported by Yahel Foundation, Recanati, New York, and by the Ministry of Science, Technology, and Space.

Primary Source

Neurology

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Best Cbd Oils For Neuropathy

The quality of CBD oil is paramount for your results with neuropathy. Unfortunately, no two CBD oils are made the same in fact, theres a large degree of difference in quality between brands. There are many great companies committed to quality, but theres an equal number of fly-by-night brands preying on uneducated customers.

Having been in the business for 7 years, weve tried a plethora of CBD oils from dozens of different brands. This year was even more demanding in terms of the tested products considering the continuously rising popularity of CBD.

Weve selected the top 5 CBD oils for neuropathy from over 40 companies that offer CBD oil in three different types: full-spectrum, broad-spectrum, and isolate. Our ranking is based on the quality criteria such as hemp sourcing, extraction methods, third-party testing, and customer service.

How To Treat Pain With Medical Marijuana

Marijuana and diabetes: Benefits, risks, and legality

Approximately 25.3 million American adults suffer from chronic pain. The Journal of Pain reports that over 126 million adults experienced some degree of pain in the previous three months.

If youre currently struggling with chronic pain, CannaMD can help. Find out for free if you qualify for medical marijuana treatment.

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Studies Of Cannabis For Neuropathic Pain

A number of studies have evaluated cannabis for treating neuropathic pain. Overall, available data support the efficacy of smoked or inhaled cannabis in its flower form when used as monotherapy or adjunctive therapy for relief of neuropathic pain of various etiologies. Many studies also report secondary benefits, including better sleep and functional improvement.,

However, adverse effects are common, especially at high doses, and include difficulty concentrating, lightheadedness, fatigue, and tachycardia. More serious reported adverse effects include anxiety, paranoia, and psychosis.

Traditional Treatments For Pain

For people with chronic pain, simply getting through each day can be a struggle. Pain takes a physical toll, but it also has a huge emotional impact often causing fatigue, anxiety and depression. Narcotic painkillers can provide powerful relief for some types of pain. Neuropathic pain can prove to be tricky, as it doesnt respond to many conventional pain medications. Even if a patients pain is well-controlled with traditional medications, the side effects often cause an entirely different set of health problems.

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Sciatica And Medical Cannabis Treatment

When pain radiates up the sciatic nerve it is called sciatica, a condition that frequently occurs due to bone spurs or herniated discs, it can affect the lower back, hips, and legs, reports the Mayo Clinic, adding while sometimes severe, it is also merely curable with non-evasive methods in a matter of weeks.

Several medications ease sciatica pain and include anti-inflammatory, muscle relaxants, narcotics, tricyclic antidepressants, and anti-seizure medications. While so many of the noted drugs cause serious side effects and can even be addicting like narcotics, medical cannabis shows to be effective in treating sciatica, as reported in 2018 by medical periodical Neurology.

The study compared two groups of men who suffer from chronic radicular nerve pain. The first group of nine men were administered 15 milligrams of THC sublingually followed by a questionnaire and a brain scan. The second group of six men were given a placebo. One week later, the process was repeated and the groups were switched . On a scale of zero to 100, before taking medication, on average participants rated their pain levels at 53, according to the report. After taking THC oil, they rated their pain levels at an average of 35 compared to an average of 43 for those who were given the placebo.

Can Marijuana Worsen Nerve Pain

The Refinery Neuropathy helps patients overcome nerve pain

When it comes to cannabis for neuropathy, some patients wonder if the plant can worsen nerve pain rather than make it better. This concern is legitimate and has been tested, but there havent been any concrete conclusions. One 2019 study claims they found a connection between high-potency cannabis and nerve damage in the brain, but these findings havent been proven elsewhere.

For now, we can confidently say that your medical marijuana isnt likely to make your neuropathy worse. With how the plants cannabinoids function in the body, you have a much higher chance of experiencing relief from cannabis than experiencing any amount of pain. However, if you do, make sure to stop consuming cannabis and contact your doctor immediately.

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What Are The Traditional Treatments For Chronic Pain

With chronic pain, the goal is always to start by treating the underlying condition, not just the pain symptom. For some conditions that cause chronic pain, there are specific medications that treat the condition. For some, treating the underlying condition provides a good response and will help decrease pain levels.

Chronic pain can often be the result of previous injuries. The easiest way to talk about treatments for these types of conditions is to break them out into:

  • Surgical
  • Non-surgical

Surgery is not generally the first choice. So, when we look at non-surgical treatments we can then break that down into:

  • Physical treatments
  • Over the counter medications
  • Prescription medications

Cbd And Thc: Side Effects And Legal Concerns

THC might not be an option for everyone, though. Some people may live in states where THC is illegal while others simply dont want the psychoactive effects of the substance. In those cases, it might be worth trying CBD on its own to see if it offers pain relief for you.

CBD isnt legal everywhere either. And in states where CBD is legal, laws can vary as to how much THC is permissible in CBD products in order for them to be legally sold. Many states in which certain CBD products are legal require them to contain less than 0.3 percent THC.

Before trying either substance, its worth considering potential side effects they may cause. Side effects of CBD include nausea, fatigue, and irritability, according to Harvard Health. CBD can also interact with certain medications and either increase or decrease the concentration of certain drugs in the bloodstream.

THC has its own set of side effects, including sleepiness and lethargy, increased appetite, increased heart rate, coordination problems, dry mouth, red eyes, slower reaction times, memory loss, anxiety, and mood changes.

Its quite likely that individuals will respond to different versions of these cannabinoids, and some may not respond at all, says Dr. Alexander. Theres a tendency for anecdotal evidence to highlight the positives of people who do respond , which is useful, but its difficult to measure the numbers of people who dont get a lasting benefit.

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How Hoes Medical Cannabis Help Nerve Pain

The endocannabinoid system aids in regulating the nervous system and also in reducing pain. When someone undergoes a nerve injury, neuropathic pain and chronic pain may often follow. Cannabinoids such as THC and CBD reduce nerve pain by activating receptors and helping to regulate the central nervous system.

Cannabis also affects the endorphin system, which may make pain feel less intense and more manageable. CBD and THC have been found to be effective at knocking out pain, but research shows that other cannabinoids may also provide chronic pain relief.

Cannabis For Chronic Pain Explained By Dr Joe

Marijuana for pain: The best strains for chronic pain relief
  • 10 Min Read |
  • About 1 in 5 Australians live with chronic pain each day.
  • There are many types of chronic pain. The most common types of pain are: arthritic pain, back pain, headaches & migraines, musculoskeletal and neuropathic pain.
  • Cannabis has been proven to reduce pain by up to 30% in some patients.
  • Cannabis is prescribed for chronic pain in Australia.
  • In this video Dr Joe Kosterich explains what chronic pain is, traditional treatments and side effects of those treatments. Dr Joe also explains how cannabis is being used in Australia to treat chronic pain.

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    What Are The Signs Of Chronic Pain

    Chronic pain is defined as pain that lasts for more than three months. There are numerous types of chronic non-cancer pain. Some of the better known types of chronic pain are:

    • Arthritic pain
    • Musculoskeletal
    • Neuropathic pain

    Explaining signs of chronic pain is difficult because it depends on what type of chronic pain youre experiencing. For example, if you have chronic low back pain you may experience pain in the lower back and it may run down the leg as well. People can experience pain in different parts of their body due to a problem in their neck. Some people get chronic pain post surgery. Other people have diseases of which chronic pain is a symptom .

    Pain is an unpleasant sensation in the body. It can affect any part of the body and the way that people experience it is different for each person.

    State Legalization Of Medical Marijuana

    Medical cannabis is currently legal in 34 states , many of which require patient registry or identification cards for the purchase and use of the substance for specific diagnosed medical conditions. These conditions differ by state and continue to change. At the federal level, marijuana is classified as a Schedule I substance under the Controlled Substances Act, and there are no recognized medical uses. In many of the states with legalized cannabis, some type of product testing is required, however, testing varies by state and may be limited contamination tests or may include quantification of CBD and THC levels.

    California, for example, requires dispensaries to sell only marijuana that has been tested for pesticides, contaminants, and microbial impurities. Beginning in July 2018, California also began to require testing to determine plant potency . This information is included on the product label.¹² In addition to the above, 12 states have enacted legislation allowing for limited use of medical marijuana .

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    What Can I Do Right Now

    The best way forward is to educate yourself on cannabis and how it impacts your nerve pain. The more you read and learn, the better your decisions regarding your health and well-being. Make sure you speak to your physician about how cannabis can make your life better.

    If you wish to learn more about cannabis and its many great benefits, speak to the local bud experts at BudBar. As the leading cannabis store in Calgary, Alberta, Canada, they can provide you with insight and value, ensuring you are well informed about cannabis consumption and the latest products.

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    Interactions With Other Drugs

    Doctors: Nerve blocks can help chronic pain

    A variety of drugs are used to treat MS and its symptoms. These include disease-modifying drugs, corticosteroids, and others that target specific symptoms and health problems related to MS, like depression, bladder problems, spasticity, sexual problems, fatigue, pain, and emotional changes . The increasing use of medicinal cannabis for MS-related symptoms, such as pain and spasticity, can produce potential interactions with medications used for other symptomatic treatment. It is well known that cannabis, especially with higher THC content, induces sedation, impairs psychomotor performance, and increases blood pressure and heart rate. Pharmacodynamic interactions with other sedatives can potentiate the central effects, but sedation can be decreased by psychostimulants . These interactions are important to emphasize on medications that are either inductors or inhibitors of the isoenzymes that metabolize THC and CBD . Most of the known interactions can be found in the prescriber information for the approved medicinal cannabis products . However, this information is not available for the medicinal cannabis with different THC/CBD compositions available in other countries. Furthermore, there is a lack of data in humans about the possible interactions between synthetic cannabinoids and cannabis, but combining them may augment t psychopharmacological activity .

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    Ellis Et Al 200: Pain Reduction In Hiv Neuropathy

    Ellis et al conducted a double-blind, placebo-controlled crossover trial in patients with HIV neuropathy that was unresponsive to at least 2 analgesics with different modes of action. During each treatment week, participants were randomly assigned to smoke either active cannabis or placebo, while continuing their standard therapy. Titration started at 4% THC and was adjusted based on tolerability and efficacy. Twenty-eight of the 34 enrolled patients completed both cannabis and placebo treatments. The principal outcome was change in pain intensity from baseline at the end of each week, using the Descriptor Differential Scale of Pain Intensity.

    Of the 28 patients, 46% achieved an average pain reduction of 3.3 points . One patient experienced cannabis-induced psychosis, and another developed an intractable cough, which resolved with smoking cessation.

    First Dance With Mary Jane

    One day, my wife was talking to one of her friends. She described my symptoms and he said: Has he tried marijuana to sleep?

    Ah, no. Ive never done pot in my life. As a kid, I saw somebody struggle tremendously with addiction and it has scared me for my entire life.

    But the more I struggled with pain, the more I started hearing about people who take edibles for pain.

    So-and-sos mom takes edibles for her back.

    So-and-so uses marijuana because she has cancer.

    So-and-sos husband took edibles for a bulging disc.

    I was shocked. And it made me start to consider it.

    Finally, I hit the breaking point. I broke down and went to a local marijuana dispensary.

    It was as easy as walking into a McDonald’s. And the menu was even bigger.

    Recreational or medicinal, a guy at the front door asked me.

    Ah, recreational, I said, because I dont have a card.

    I was directed into the recreational line, although I was hoping for medicinal benefit.

    Im not sure what I was expecting. I guess, I thought it would be a dark, creepy, smoke-filled store. Or maybe, I pictured some dude in a back-parking lot, selling stuff out of his van. But this store felt like an upscale convenience store and five cashiers stood behind a counter. There were at least 10 people waiting in line. I found it surprising that most of the customers were in their 50s or older.

    An edible? she asked.

    Yes. Im not looking to get high.

    Take one, I was told. It will help with inflammation and pain.

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    Can Medical Marijuana Help With Trigeminal Neuralgia

    What exactly if trigeminal neuralgia? Well, to begin with, it is essential that we get a clear definition of what it is. Neuralgia happens to be a term used to refer to a nerve pain that could basically occur in any part of the human body. On the other hand, neuralgia is the fifth cranial trigeminal nerve which happens to be the largest of them all. It plays a very essential role in showing sensations on the face. Besides, it is a nerve that functions effectively for chewing and biting to happen. Trigeminal neuralgia is a chronic pain disorder that involves the damage of the trigeminal nerve. More often than not, people suffering from HIV/AIDS, diabetes as well as multiple sclerosis are at a higher risk of being affected by this condition. This is because the myelin sheath that surrounds the Trigeminal nerve has ceased to function as it is damaged. Also, old age can be one of the factors that could cause this condition to occur.

    ADVANTAGES OF USING MEDICAL CANNABIS TO RELIEVE TRIGEMINAL NEURALGIA

    Cannabis contains strains that include cannabidiol and tetrahydrocannabidiol that are abbreviated as CBD and THC. THC is responsible for increased psycho-activity to a user whereas CBD tends to counteract that particular psycho-activity thus making cannabis to be an important substance to use to relieve pain, seizures, spasms as well as inflammation without leaving the feeling of lethargy behind.

    WHAT DOES RESEARCH SAY?

    SIDE EFECTS OF USING MEDICAL CANNABIS

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